Table 4 Annual changes in eGFR according to the cause of CKD.

From: Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD

 

Annual changes of eGFR (mL/min/1.73 m2 per year)

Unadjusted

Adjusted¶

Estimate (SE)

P value

Estimate (SE)

P value

Cause of CKD

 

< 0.001a

 

< 0.001a

Glomerulonephritis

− 2.19 (0.106)

 

− 2.16 (0.106)

 

Hypertensive nephropathy

− 1.44 (0.151)

< 0.001b

− 1.42 (0.152)

< 0.001b

Diabetic nephropathy

− 3.17 (0.16)

< 0.001b

< 0.001c

− 3.07 (0.161)

< 0.001b

< 0.001c

Polycystic kidney disease

− 3.45 (0.155)

< 0.001b

< 0.001c

0.201d

− 3.37 (0.156)

< 0.001b

< 0.001c

0.176d

  1. Adjusted with age, sex, body mass index, CKD stage, mean blood pressure, cardiovascular disease, hemoglobin, uric acid, calcium, phosphorous, albumin, total cholesterol, high-density lipid cholesterol, low-density lipid cholesterol, fasting blood sugar, intact parathyroid hormone, urine protein-to-creatinine ratio, high sensitivity C-reactive protein, diuretics use, statin use, and ACE inhibitor or ARB use.
  2. aP value for the interaction term between the cause of CKD and time effect in the mixed model.
  3. bP value for each estimated of CKD causes compared to the glomerulonephritis as reference.
  4. cP value for each estimated of CKD causes compared to the hypertensive nephropathy as reference.
  5. dP value for each estimated of CKD causes compared to the diabetic nephropathy as reference.
  6. ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; SE, Standard error.
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