Figure 1 | Scientific Reports

Figure 1

From: Reversal of aging-associated increase in myelopoiesis and expression of alarmins by angiotensin-(1–7)

Figure 1

Aging alters expression of angiotensin receptors and ACEs in bone marrow cells: (A) Representative western blots for MasR and AT1R protein expressions in the bone marrow Lineage-depleted cells (A) and ACE and ACE2 (C) protein levels in the bone marrow supernatants derived from Young and Old mice. (B) Protein expression of both MasR and AT1R was higher in the Old cells compared to the Young, was decreased to levels similar to that observed in Young by Ang-(1–7) treatment (P < 0.05 and P < 0.01 for MasR and AT1R, respectively, n = 6). Groups were compared by One-way ANOVA followed by Tukey’s post-test. (D) ACE protein levels in the bone marrow supernatant were higher in the Old compared to the Young (P < 0.05, n = 8) while ACE2 levels were unchanged. Statistical differences were tested by using unpaired Students’ ‘t’-test.

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