Figure 8
Summary of findings. Aging in mice is associated with imbalance in ACE2/ACE in the BM-environment and increased myelopoiesis and alarmin expression in the hematopoietic progenitor cells. Increased generation of monocyte-macrophages resulted in systemic inflammation and tissue infiltration of monocyte-macrophages. Recruitment of macrophages to areas of ischemic injury was higher in the Old mice, which resulted in impaired recovery. Ang-(1–7) via activation of MasR reversed aging-associated changes in alarmin expression, myelopoiesis and recruitment of monocyte-macrophages following ischemic insult.
