Table 2 Parameters rmax, t1/2, and A for aggregation of 10 µM Aβ40 in the presence of different concentrations of Ni(II) acetate.

From: Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptides

Ni(II)

0 µM

1 µM

2.5 µM

5 µM

7.5 µM

10 µM

20 µM

50 µM

rmax [h−1]

0.96 ± 0.22

1.08 ± 0.36

0.88 ± 0.34

1.0 ± 0.45

1.02 ± 0.85

0.96 ± 0.58

n/a

n/a

t1/2 [h]

8.3 ± 1.5

10.2 ± 0.3

11.8 ± 1.2

11.2 ± 0.7

12.5 ± 0.5

13.5 ± 1.4

n/a

n/a

A

4115 ± 436

2967 ± 238

2085 ± 575

1449 ± 480

1511 ± 132

1803 ± 442

n/a

n/a

  1. The parameters were obtained from sigmoidal curve-fitting (Eq. 2) to the ThT curves shown in Fig. 5.
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