Table 1 Quantitative histopathological assessment of staining sections observed in DEP- and APM-instilled mice.
Group | VC | DEP 1.25 | DEP 2.5 | DEP 5 | APM 1.25 | APM 2.5 | APM 5 |
|---|---|---|---|---|---|---|---|
Accumulation of particle-pigment alveolar macrophages and black particles in the alveolar lumen | |||||||
Minimal | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Slight | 0 | 4 | 1 | 0 | 1 | 0 | 0 |
Moderate | 0 | 0 | 2 | 4 | 4 | 5 | 1 |
Severe | 0 | 0 | 0 | 1 | 0 | 0 | 4 |
Mean ± SD | 0 | 1.8 ± 0.45## | 1.6 ± 1.52## | 3.2 ± 0.45#### | 2.8 ± 0.45#### | 3 ± 0.00#### | 3.8 ± 0.45#### |
Inflammatory cell infiltration, perivascular | |||||||
Minimal | 0 | 2 | 2 | 1 | 1 | 2 | 0 |
Slight | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
Moderate | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mean ± SD | 0 | 0.4 ± 0.55 | 0.4 ± 0.55 | 0.8 ± 1.30 | 0.2 ± 0.45 | 1.2 ± 0.84 | 0.8 ± 1.09 |
Granulomatous inflammation | |||||||
Minimal | 0 | 0 | 0 | 0 | 0 | 1 | 2 |
Slight | 0 | 0 | 0 | 0 | 1 | 2 | 2 |
Moderate | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mean ± SD | 0 | 0 | 0 | 0 | 0.4 ± 0.89 | 1.60 ± 1.14## | 1.2 ± 0.4# |
Pulmonary fibrosis | |||||||
Minimal | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Mean ± SD | 0 | 0 | 0 | 0 | 0 | 0 | 0.4 ± 0.55 |
Mucous cell hyperplasia | |||||||
Minimal | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mean ± SD | 0 | 0 | 0 | 0 | 0 | 0.2 ± 045 | 0 |
