Table 2 GO functional category analysis of DEP- or APM-altered genes.
Term | Count | % | p-value | Genes |
|---|---|---|---|---|
A. BPs of DEP | ||||
Inflammatory response | 6 | 20 | 1.15E−04 | Ptgir, Vnn1, Ccl22, Cxcl1, Cd14, Cxcl5 |
Immune system process | 4 | 13.3 | 0.017 | Marco, Clec4d, Cd14, Cd300lf |
Chemokine-mediated signaling pathway | 3 | 10 | 0.003 | Ccl22, Cxcl1, Cxcl5 |
Cell chemotaxis | 3 | 10 | 0.006 | Ccl22, Cxcl1, Cxcl5 |
Positive regulation of ERK1 and ERK2 cascade | 3 | 10 | 0.030 | Ccl22, Gpnmb, Trem2 |
Acute inflammatory response | 2 | 6.67 | 0.024 | Vnn1, Cxcl1 |
Response to tumor necrosis factor | 2 | 6.67 | 0.035 | Wfdc21, Cd14 |
B. KEGG pathway of DEP | ||||
Cytokine-cytokine receptor interaction | 5 | 16.67 | 0.002 | Ccl22, Cxcr1, Il12b, Cxcl1, Cxcl5 |
Chemokine signaling pathway | 4 | 13.3 | 0.009 | Ccl22, Cxcr1, Cxcl1, Cxcl5 |
C. BPs of APM | ||||
Immune system process | 22 | 9.13 | 3.59E−09 | C1qb, Cd86, C1qa, Cd84, Clec4n, Ly96, Ctps, Tmem173, Lilrb4a, Serpina3g, Cfp, Pirb, Adgre1, Lat2, Lgals3, Clec4d, Aim2, Olr1, Irf5, Cd300lf, C1qc, Tlr2 |
Inflammatory response | 18 | 7.47 | 5.15E−07 | Ptgir, Slc11a1, Ly96, Cyba, Tnfrsf1b, Lipa, Ptgs1, Ccl9, Aim2, Clec7a, C3ar1, Spp1, Ccl3, Olr1, Tspan2, Ackr1, Tnfrsf26, Tlr2 |
Positive regulation of angiogenesis | 10 | 4.15 | 1.10E−05 | Acvrl1, Lgals3, Lrg1, Cxcr2, Itgb2, C3ar1, Kdr, Hmox1, Ctsh, Alox12 |
Cell surface receptor signaling pathway | 10 | 4.15 | 1.01E−03 | Adgre1, Cd53, Cd274, Fcer1g, Adgre5, Tspan7, Cxcr2, Tspan2, Fcgr2b, Tnfrsf1b |
Neutrophil chemotaxis | 8 | 3.32 | 1.42E−05 | Lgals3, Ccl9, Fcer1g, Cxcr2, Itgb2, Spp1, Ccl3, Nckap1l |
Positive regulation of ERK1 and ERK2 cascade | 8 | 3.32 | 6.19E−03 | Ccl9, Fam150a, Gpnmb, Kdr, Ccl3, Trem2, Cd44, Tlr2 |
Positive regulation of tumor necrosis factor production | 6 | 2.49 | 5.80E−04 | Fcer1g, Ccl3, Ly96, Cyba, Clu, Tlr2 |
Positive regulation of NF-kappaB transcription factor activity | 6 | 2.49 | 8.54E−03 | Tgfbr3, Cd84, Aim2, Itgb2, Clu, Tlr2 |
Collagen catabolic process | 5 | 2.07 | 1.51E−04 | Ctsk, Mmp19, Mmp8, Ctss, Ctsb |
Epithelial cell differentiation | 5 | 2.07 | 7.41E−03 | Cd63, Lgals3, Krt14, Six1, Ctsb |
Cell–matrix adhesion | 5 | 2.07 | 1.25E−02 | Cd63, Col3a1, Itgb2, Itga2b, Hpse |
Positive regulation of smooth muscle cell proliferation | 5 | 2.07 | 1.36E−02 | C3ar1, Hmox1, Cyba, Alox12, Igf1 |
Positive regulation of protein kinase B signaling | 5 | 2.07 | 2.57E−02 | F10, Hcls1, Igf1, Hpse, Pik3r5 |
Positive regulation of MAPK cascade | 5 | 2.07 | 3.21E−02 | Cd84, Igfbp3, Kdr, Igf1, Tnfrsf1b |
Phagocytosis, engulfment | 4 | 1.66 | 1.49E−02 | Gsn, Fcer1g, Trem2, Fcgr2b |
Positive regulation of nitric oxide biosynthetic process | 4 | 1.66 | 1.49E−02 | Itgb2, clu, klf2, tlr2 |
Positive regulation of interleukin-6 production | 4 | 1.66 | 2.19E−02 | Il33, Fcer1g, Cyba, Tlr2 |
Macrophage chemotaxis | 3 | 1.24 | 1.09E−02 | Lgals3, Ednrb, Ccl3 |
Extracellular matrix disassembly | 3 | 1.24 | 2.62E−02 | Mmp12, Mmp19, Lcp1 |
Response to interferon-gamma | 3 | 1.24 | 3.57E−02 | Cd86, Slc11a1, Cxcl16 |
B cell homeostasis | 3 | 1.24 | 3.57E−02 | Nckap1l, Bcl2a1a, Pirb |
Cellular response to fibroblast growth factor stimulus | 3 | 1.24 | 4.64E−02 | Nr4a1, Sfrp1, Cd44 |
T cell differentiation involved in immune response | 2 | 0.83 | 4.52E−02 | Clec4d, Fcer1g |
D. KEGG pathway of APM | ||||
Lysosome | 14 | 5.81 | 0.000 | Cd63, Hexb, Slc11a1, Ctsz, Lipa, Ctss, Gnptab, Ctsk, Ctsh, Cd68, Atp6v0d2, Ctsd, Gla, Ctsb |
Phagosome | 12 | 4.98 | 0.000 | Msr1, Tuba1c, Tubb6, Clec7a, Mrc1, Itgb2, Olr1, Cyba, Fcgr2b, Atp6v0d2, Ctss, Tlr2 |
Toll-like receptor signaling pathway | 8 | 3.32 | 0.001 | Cd86, Ctsk, Spp1, Ccl3, Ly96, Irf5, Tlr2, Pik3r5 |
