Figure 3 | Scientific Reports

Figure 3

From: IRF4 as a novel target involved in malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma

Figure 3

Screening of hub genes assisted with TCGA database. (A) Hierarchical clustering analysis of the differentially expressed genes between normal and OSCC from TCGA database. (B) GSEA analysis of OSCC in TCGA database. (C) Copy number variation (CNV) frequency of the 16 genes in TCGA cohort. CNV gain, red; CNV loss, blue color. The height of the column represents the alteration frequency. (D) Mutation frequency and classification of the 16 genes in OSCC. (E) Univariate Cox analysis of 16 DEGs with prognostic significance in TCGA OSCC datasets. (F) Multivariate Cox analysis 16 DEGs with prognostic significance in TCGA OSCC datasets.

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