Table 3 2 × 2 contingency tables between each assays with resulting diagnostic performance with each assay set as truth.
From: Sensitivity and performance of three novel quantitative assays of SARS-CoV-2 nucleoprotein in blood
a | Quanterix Simoa | Solsten ELISA | |||||
|---|---|---|---|---|---|---|---|
Solsten ELISA | pos | neg | Quanterix Simoa | pos | neg | ||
pos | 129 | 18 | pos | 129 | 18 | ||
neg | 18 | 107 | neg | 18 | 107 | ||
Sensitivity | 87.8% | 81.3% to 92.6% | Sensitivity | 87.8% | 81.3% to 92.6% | ||
Specificity | 85.6% | 78.2% to 91.2% | Specificity | 85.6% | 78.2% to 91.2% | ||
b | Quanterix Simoa | Elecsys ECLIA | |||||
|---|---|---|---|---|---|---|---|
Elecsys ECLIA | pos | neg | Quanterix Simoa | pos | neg | ||
pos | 111 | 0 | pos | 111 | 36 | ||
neg | 36 | 125 | neg | 0 | 125 | ||
Sensitivity | 75.5% | 67.7% to 82.2% | Sensitivity | 100.0% | 96.7 to 100.0% | ||
Specificity | 100.0% | 97.1% to 100.0% | Specificity | 77.6% | 70.4 to 83.8% | ||
c | Solsten ELISA | Elecsys ECLIA | |||||
|---|---|---|---|---|---|---|---|
Elecsys ECLIA | pos | neg | Solsten ELISA | pos | neg | ||
pos | 110 | 1 | pos | 110 | 37 | ||
neg | 37 | 124 | neg | 1 | 124 | ||
Sensitivity | 74.8% | 67.0% to 81.6% | Sensitivity | 99.1% | 95.1% to 100.0% | ||
Specificity | 99.2% | 95.6% to 100.0% | Specificity | 77.0% | 69.7% to 83.3% | ||
Comparison | Fisher's exact test* | Cohens Kappa** | McNemar*** | ||||
|---|---|---|---|---|---|---|---|
Quanterix Simoa vs Solsten ELISA | < 0.00001 | 0.73 | 0.87 | ||||
Quanterix Simoa vs Elecsys ECLIA | < 0.00001 | 0.74 | < 0.0001 | ||||
Solsten ELISA vs Elecsys ECLIA | < 0.00001 | 0.72 | < 0.0001 | ||||
