Table 1 OARSI histological assessments of osteoarthritis.

From: Protective effects of Pudilan Tablets against osteoarthritis in mice induced by monosodium iodoacetate

Grade

Osteoarthritic damage

0

Normal

0.5

Loss of Safranin-O without structural changes

1

Small fibrillations without loss of cartilage

2

Vertical clefts down to the layer immediately below the superficial layer and some loss of surface lamina

3

Verical clefts/erosion to the calcified cartilage extending to < 25% of the articular surface

4

Vertical clefts/erosion to the calcified cartilage extending to 25–50% of the articular surface

5

Vertical clefts/erosion to the calcified cartilage extending to 50–75% of the articular surface

6

Vertical clefts/erosion to the calcified cartilage extending > 75% of the articular surface