Figure 6 | Scientific Reports

Figure 6

From: Osteoprotegerin deficiency aggravates methionine–choline-deficient diet-induced nonalcoholic steatohepatitis in mice

Figure 6

Osteoprotegerin (OPG) regulates MAPK signaling pathway activity via DUSP14. (A) OPG and dual specificity phosphatase 14 (DUSP14) protein levels in the mice. (B) Phosphorylation levels of extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinase 1 (JNK), and P38 in mouse liver. (C) OPG and DUSP14 proteins in OPG-overexpressing hepatocytes. (D) Phosphorylation levels of ERK, JNK, and P38 in OPG-overexpressing hepatocytes. (E) OPG and DUSP14 proteins in DUSP14 knockout hepatocytes. (F) Phosphorylation levels of ERK, JNK, and P38 in DUSP14 knockout hepatocytes. Each group at least has 3 samples. The data in (A–F) are presented as the mean ± SD; ns no significant difference, *p < 0.0, **p < 0.01, and ***p < 0.001.

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