Table 5 Regression parameters for estimation of MET, PIO and GLM in spiked human plasma using the developed method.

From: Deduction of the operable design space of RP-HPLC technique for the simultaneous estimation of metformin, pioglitazone, and glimepiride

Drug

MET

PIO

GLM

Concentration range (µg/mL)

0.050–2.000

0.050–2.000

0.040–2.000

r

0.9999

0.9999

0.9999

a

0.075

0.150

0.184

b

2.665

1.614

2.312

Sa

0.014

0.009

0.012

Sb

0.014

0.010

0.014

S(y/x)

0.022

0.017

0.024

LOD

0.017

0.019

0.017

LOQ

0.052

0.058

0.051

  1. r: correlation coefficient; b: slope; a: intercept; Sb: standard deviation of slope; Sa: standard deviation of intercept; Sy/x: residual standard deviation; LOQ: limit of quantitation; LOD: limit of detection.
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