Table 2 The EC change (logratio) with respect to the original strain for each mutated amino acid residue is reported.

Strain	Mutated residue	modEC	effect
Alpha	501	− 1.89267	Null
Alpha	570	− 0.16767	Null
Alpha	614	− 0.375	Null
Alpha	716	0.060667	Null
Alpha	1118	0.095333	Null
Delta	142	− 0.352	Null
Delta	452	0.321667	Null
Delta	614	0.321667	Null
Delta	950	0.028	Null
Omicron	67	− 0.786	Null
Omicron	142	− 1.08433	Null
Omicron	339	2.449667	Positive
Omicron	371	3.125667	Positive
Omicron	373	2.703333	Positive
Omicron	375	2.721333	Positive
Omicron	417	3.207	Positive
Omicron	440	2.709667	Positive
Omicron	493	2.906333	Positive
Omicron	496	2.876	Positive
Omicron	498	2.930667	Positive
Omicron	501	2.826	Positive
Omicron	547	1.134667	Null
Omicron	614	− 2.14667	Negative
Omicron	655	− 2.32667	Negative
Omicron	764	− 0.82067	Null
Micron	796	− 3.03567	Negative
Omicron	856	1.23533	Null
Omicron	954	0.017667	Null
Omicron	969	3.31266	Null

The absence of any relevant change in EC of the Alpha and Delta strain is worth than nothing, while 14/21 (67%) Omicron mutations imply a significant change with respect to the original strain. Moreover the distribution of positive and negative changes is far from random, positive changes being concentrated in RBD domain, while negative changes are only found in the splicing domain.

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