Figure 4 | Scientific Reports

Figure 4

From: Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib

Figure 4

Inhibition of PI3Kγ reduces the motility of MCL cells. (A) Migration of Maver-1, Mino and Jeko-1 cell lines to CCL21 (1 µM) in the presence of the indicated inhibitors (mean ± SD of n = 3 separate experiments). (B) Migration of primary MCL cells to CCL21 in the presence of the indicated inhibitors (mean ± SD, n = 6 patients). Due to the variation in the number of cells migrating from the different patients’ data are normalised against migration of untreated cells to CCL21; circles represent the migration of cells from each of the individual patients (data for individual patients can be found in Supplementary Figure 4D). *P < 0.05. Statistical significance was determined using the paired Student’s T-Test; for (B) the test was performed on the raw data.

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