Figure 1 | Scientific Reports

Figure 1

From: Identification of two early blood biomarkers ACHE and CLEC12A for improved risk stratification of critically ill COVID-19 patients

Figure 1The alternative text for this image may have been generated using AI.

Differential expression analysis and principal component analysis of COVID-19 patients at day 0 and day 7 of ICU admission. (a) Volcano plot showing the transcriptomic differences of COVID-19 patients upon ICU admission (day 0, n = 24 (survivor n = 12, non-survivor n = 12)). (b) Volcano plot showing the transcriptomic differences of COVID-19 patients at day 7 in ICU (n = 24 (survivor n = 12, non-survivor n = 12)). Blue dots represent differentially expressed genes with a significantly increased expression level in survivors, while red dots represent genes with a significantly increased expression level in non-survivors (adjusted p-value ≤ 0.01 and a log2 fold change ≤  − 1 or ≥ 1). (c) Principal component analysis using the differentially expressed genes between COVID-19 patients with different outcomes at day 0 (% variance explained: PC1 = 72.44, PC2 = 7.69, PC3 = 4.15). (d) Principal component analysis using the differentially expressed genes between COVID-19 patients with different outcomes at day 7 (% variance explained: PC1 = 43.17, PC2 = 13.29, PC3 = 9.37). Blue spheres indicate survivors and red pyramids represent non-survivors. A centroid is shown for both conditions, connected to each data point by a line.

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