Figure 4
ROC curve analysis and boxplots for the evaluation of three standard of care markers for patients with different clinical outcomes. (a) Evaluation for C-reactive protein (CRP) for survivors and non-survivors at different sampling times. Values are shown in mg/dL. (b) Evaluation for procalcitonin (PCT) for survivors and non-survivors at different sampling times. Values are shown in ng/mL. (c) Evaluation for sequential organ failure assessment (SOFA) score for survivors and non-survivors at different sampling times. ROC curve analysis was performed for both time points separately (day 0 = long dashed line, day 7 = short dashed line) and combined (day 0 + 7 = solid line). Both sampling time points are shown separately in two boxplots. Differences between the mean values of the two outcome groups (survivors and non-survivors) were assessed with a two-sided Wilcoxon test separately for day 0 and day 7 with n = 24 (survivors n = 12, non-survivors n = 12). Additionally, unequal variance t-tests were performed (pCRP,day0 = 0.96, pCRP,day7 = 1.45⋅10–5, pPCT,day0 = 0.72, pPCT,day7 = 0.02, pSOFA,day0 = 0.09, pSOFA,day7 = 1.14⋅10–6).
