Figure 3

The analgesic effects of UK4b (10 or 20 mg/kg) compared to vehicle control and morphine (5 mg/kg) in the mouse model of postoperative pain (n ≥ 6 for each group). All treatments were administered subcutaneously (SC). (A) Paw withdrawal latency (PWL) and (B) 50% mechanical sensitization threshold (grams) in the post-treatment model, with surgery occurring on Day 0 and daily treatment from Days 1 to 7. (C) Paw withdrawal latency (PWL) and (C) 50% mechanical sensitization threshold (grams) in the pre- and post-treatment model, with surgery occurring on Day 0 and daily treatment from Days 0 to 7. PWL and mechanical sensitization were measured at 2 h after surgery (Day 0) or 2 h after each daily treatment with UK4b or morphine or vehicle (Days 1 to 7). Statistical significance (two-way ANOVA): *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.