Figure 4

The effects of UK4b on the concentrations (pg/mg) of prostanoids (PGE₂, PGD₂, PGF_2α, PGI₂, TXA₂) in tissues. (A) PGE₂, (B) PGD₂, (C) PGF_2α, (D) PGI₂, (E) TXA₂ concentrations in paw tissue collected from carrageenan-injected rats at 26 h after the carrageenan injection: the (−) control group (without carrageenan injection) provides the baseline concentrations, the (+) control group received carrageenan injection and was treated with vehicle, and the UK4b group was treated with 10 mg/kg UK4b (IP) 4 h before carrageenan injection (n ≥ 4 for each group). (F) PGE₂ concentrations in the paw tissue collected at 48 h (Day 2) from four groups of mice after the surgery in the model of postoperative pain: Sham–sham surgery group; vehicle—surgery group treated with vehicle; Pre + post UK4b—pre- and post-treatment group received daily treatment with 20 mg/kg UK4b from Days 0 (2 h before surgery) to 2; and Post UK4b—post-treatment group treated with 20 mg/kg UK4b on Days 1 and 2 (n ≥ 6 for each group). Statistical significance (one-way ANOVA): *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.