Table 3 Comparison of foveal avascular zone area and vessel densities of the superficial, deep retinal capillary plexus and radial peripapillary capillary segment between preterm patients with a history of retinopathy of prematurity with treatment, spontaneously regressed, and full-term healthy controls.

	tROP patients (n = 38)	srROP Patients (n = 40)	Healthy controls (n = 43)	tROP vs. HC	srROP vs. HC	tROP vs. srROP	Adjusted p value^a
FAZ area (mm²)	0.09 ± 0.07	0.13 ± 0.11	0.33 ± 0.11	− 0.24 (0.02) p < 0.0001	− 0.21 (0.02) p < 0.0001	0.03 (0.02)	< 0.0001
SRCP, % area
FAZ (foveal)	28.93 ± 5.31	28.72 ± 5.1	21.40 ± 4.16	7.51 (1.09) p < 0.0001	7.22 (1.09) p < 0.0001	− 0.29 (1.12)	< 0.0001
Parafoveal (average)	46.29 ± 2.07	46.61 ± 2.32	48.97 ± 2.04	− 2.42 (0.48) p < 0.0001	− 2.70 (0.48) p < 0.0001	0.27 (0.50)	< 0.0001
DRCP, % area
FAZ (foveal)	23.84 ± 6.02	22.52 ± 6.02	15.86 ± 4.56	6.87 (1.24) p < 0.0001	8.03 (1.25) p < 0.0001	− 1.16 (1.28)	< 0.0001
Parafoveal (average)	50.79 ± 2.16	49.63 ± 2.50	52.02 ± 2.63	− 1.20 (0.55)	− 2.26 (0.55) p = 0.0002	− 1.05 (0.56)	0.0004
RPC, % area
Center	30.66 ± 10.54	33.10 ± 11.24	40.79 ± 10.85	− 10.17 (2.52) p = 0.0002	− 7.99 (2.51) p = 0.0058	2.18 (2.56)	0.0002
Peripapillary (average)	58.53 ± 3.44	57.59 ± 4.19	61.35 ± 2.50	− 2.75 (0.76) p = 0.0012	− 3.40 (0.75) p < 0.0001	− 0.65 (0.78)	< 0.0001

tROP, retinopathy of prematurity with laser treatment; srROP, spontaneously regressed retinopathy of prematurity; HC, healthy controls; FAZ, foveal avascular zone; SRCP, superficial retinal capillary plexus; DRCP, deep retinal capillary plexus; RPC, radial peripapillary capillary; SE, standard error; CI, confidence interval.
Values are shown as mean ± standard deviation.
^ap value was calculated by multivariate linear regression with adjustment for age and Bonferroni correction multiplied by 3.
Boldface indicates statistical significance.

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