Table 1 The summary of pathway impact on 2D culture and 3D MCS.

From: The impact of hypoxia and oxidative stress on proteo-metabolomic alterations of 3D cholangiocarcinoma models

Pathways

Hits

Raw p

Holm adjust

FDR

Impact

Aminoacyl-tRNA biosynthesis

12

3.08E-08

2.58E-06

2.58E-06

0

Arginine biosynthesis

7

1.36E-07

1.13E-05

5.73E-06

0.48223

Phenylalanine, tyrosine, and tryptophan biosynthesis

3

0.00017

0.01354

0.00462

 

Alanine, aspartate, and glutamate metabolism

6

0.00031

0.0253

0.00655

0.6234

Valine, leucine, and isoleucine biosynthesis

3

0.00208

0.1671

0.03452

0

Glutathione metabolism

5

0.00246

0.1948

0.03452

0.33951

Phenylalanine metabolism

3

0.00425

0.3317

0.05104

0.61904

  1. Hits is the matched number from the user uploaded data; Raw p is the original p value calculated from the enrichment analysis; Holm p is the p value adjusted by Holm-Bonferroni method; the FDR is the p value adjusted using False Discovery Rate; Impact is the pathway impact value calculated from pathway topology analysis.
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