Table 3 Performance of diagnostic factors for DED related to graft-versus-host disease in pediatric patients.

From: Pediatric chronic graft-versus-host disease-related dry eye disease and the diagnostic association of potential clinical findings

 

Cutoff

Sensitivity (95% CI)

Specificity (95% CI)

 + LR (95% CI)

 − LR (95% CI)

Relative risk (95% CI)

AUC (95% CI)

Cotton thread test

 ≤ 10 mm

0.71 (0.38–1.00)

0.89 (0.68–1.00)

6.43 (0.96–43.23)

0.32 (0.10–1.06)

4.17 (1.15–15.13)

0.96 (0.873–1)

 ≤ 17 mm

0.94 (0.77–1.00)

0.85 (0.63–1.00)

6.25 (1.41–27.63)

0.07 (0.01–1.09)

15.00 (1.00–225.3)

Filamentary keratitis

Positive

0.46 (0.18–0.74)

0.97 (0.88–1.00)

14.67 (0.90–240.38)

0.56 (0.33–0.95)

3.10 (1.56–6.18)

–

Pseudomembranous conjunctivitis

Positive

0.54 (0.26–0.82)

0.97 (0.88–1.00)

17.33 (1.08–278.66)

0.47 (0.25–0.88)

3.55 (1.68–7.48)

–

  1. DED dry eye disease; + LR positive likelihood ratio; − LR negative likelihood ratio; AUC area under the receiver operating characteristic curve.
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