Figure 3 | Scientific Reports

Figure 3

From: Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes

Figure 3

Mutational profiles and clinical outcomes in DMG. (A) UpSet plot of the intersection of the four predominant mutations (EGFR, TP53, ACVR1, PIK3CA/PIK3R1) observed in H3-WT midline gliomas. (B) Kaplan–Meier overall survival analysis comparing H3K27M DMG (N = 27), EPD (N = 16) and the glioma tumour cohort (N = 38). (C) Kaplan–Meier overall survival analysis comparing the mutations of interest in this study, respectively H3.3 K27M (N = 21), H3.1 K27M (N = 6), H3-WT ACVR1 (N = 16) and H3-WT EGFR (N = 11). (D) Violin plot showing the age distribution of H3-WT ACVR1 (N = 11), H3-WT EGFR (N = 10), H3.1 K27M (N = 18), and H3.3 K27M (N = 36). Horizontal line is the median age and the ends of the box represent the upper and lower quartiles. A black dot indicates the age being greater than two standard deviations from the mean age of the group.

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