Table 2 Toxicity profile of 30 evaluable patients.
Toxicity | Any grade, n (%) | ≥ Grade 3, n (%) |
|---|---|---|
Hypertension | 15 (50.0) | 9 (27.3) |
ECG T-wave abnormality | 9 (30.0) | – |
Hypothyroidism | 8 (26.7) | 2 (6.7) |
Elevated alanine aminotransferase or aspartate aminotransferase | 7 (23.3) | 1 (3.3) |
Elevated thyroid-stimulating hormone | 7 (23.3) | – |
Fatigue | 5 (16.7) | – |
Elevated γ-glutamyltransferase | 4 (13.3) | – |
Hyperbiliubinemia | 4 (13.3) | – |
Hand-foot syndrome | 3 (10.0) | – |
Hypertriglyceridemia | 3 (10.0) | – |
Hyperthyroidism | 3 (10.0) | – |
Elevated B-type natriuretic peptide | 3 (10.0) | 1 (3.3) |
Elevated alkaline phosphatase | 3 (10.0) | – |
Hyperuricemia | 3 (10.0) | – |
Leukopenia | 3 (10.0) | – |
Sinus bradycardia | 3 (10.0) | – |
Odynophagia | 2 (3.3) | – |
Lymphopenia | 2 (6.7) | – |
Hypercholesterolemia | 2 (6.7) | – |
Diarrhea | 2 (6.7) | – |
Elevated Troponin T | 2 (6.7) | – |
Ventricular arrhythmia | 2 (6.7) | – |
Neutropenia | 2 (6.7) | – |
Gastrointestinal bleeding | 1 (3.3) | – |
Hypoalbuminemia | 1 (3.3) | – |
Oral mucositis | 1 (3.3) | – |
Nausea or vomiting | 1 (3.3) | – |
Rash and pruritis | 1 (3.3) | 1 (3.3) |
Swollen gums | 1 (3.3) | – |
Hyponatremia | 1 (3.3) | – |
Hypophosphatemia | 1 (3.3) | – |
Hypoferremia | 1 (3.3) | – |
Thrombocytopenia | 1 (3.3) | – |
Anaemia | 1 (3.3) | 1 (3.3) |
Sinus tachycardia | 1 (3.3) | – |
