Figure 1

Blood pressure and heart rate before and during treatment with antihypertensive drugs, and heart-to-body weight ratio. (A,B) During treatment, both systolic and diastolic blood pressure were significantly lower in SHR treated with amlodipine and atenolol when compared to the untreated hypertensive control group. (C) Heart rate was significantly lower in atenolol treated SHR and was comparable to the heart rate of normotensive control rats. (D) Heart weights were normalized to the body weight. Untreated SHR showed higher heart-to-body weights as compared to all other groups, which was partially normalized by treatment with amlodipine and atenolol. n = 12 for WKY Ctrl and SHR Amlo, and n = 11 for SHR Ctrl and SHR Aten. ***p ≤ 0.001, *p ≤ 0.05 (A–C mixed-effects model with Bonferroni correction, D one-way ANOVA with Bonferroni correction).