Figure 6
Volume measurements of the brain and specific anatomical structures. (A–D) Representative single slices of the brains of normotensive WKY, untreated SHR, amlodipine and atenolol treated SHR, respectively. (E) Total intracranial volumes were significantly smaller in all SHR groups when compared to control WKY. (F) Lateral ventricles were substantially enlarged in both untreated and treated rats. (G) No differences were noted in the third ventricle volume between the four groups. (H) The brain parenchyma volume was significantly decreased in untreated, control SHR, as well as amlodipine and atenolol treated SHR. (I,J) The corpus callosum volume was smaller in control and amlodipine treated SHR, while the hippocampal volume was significantly decreased in untreated hypertensive rats only. n = 12 for WKY Ctrl and SHR Amlo, and n = 11 for SHR Ctrl and SHR Aten. ***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05 (E–J one-way ANOVA with Bonferroni correction). IC intracranial, LV lateral ventricle, 3V third ventricle, BP brain parenchyma, cc corpus callosum, Hc hippocampus.
