Figure 7
Amyloid-β1–40, amyloid-β1–42, and neurofilament light expression levels in the brain and CSF. (A,B) Amyloid-β1–40 (Aβ1–40) and amyloid-β1–42 (Aβ1–42) concentrations in brain homogenates were not different between the four groups. (C) Additionally, the Aβ1–40/Aβ1–42 ratios were similar in all groups. (D) Neurofilament light (NfL) levels were significantly elevated in the cerebrospinal fluid (CSF) of untreated and treated SHR as compared to WKY. n = 11–12 for WKY Ctrl, n = 10–11 for SHR Ctrl and SHR Aten, n = 12 for SHR Amlo. **p ≤ 0.01, *p ≤ 0.05 (A–C one-way ANOVA with Bonferroni correction, D Kruskal–Wallis test with Dunn’s correction).
