Figure 1 | Scientific Reports

Figure 1

From: Maximum dose, safety, tolerability and ketonemia after triheptanoin in glucose transporter type 1 deficiency (G1D)

Figure 1

C7 dose-finding. Subjects are divided in 3 age groups as described in the methods. Each circle represents one subject. Left: 14 group A G1D individuals studied at the 35% dose19. One DLT was observed in age group AII. Right: Tolerance of the 45% dose in group B following the 3 + 3 design. The MTD was determined at 45% in groups BI and BIII after all 3 subjects in each group tolerated this dose. Due to one DTL in group BII, an additional 3 subjects were added to this group, following after tolerance, in a determination of the same MTD for this age group. DLT Dose limiting toxicity.

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