Figure 3
From: Mangiferin relieves CCl4-induced liver fibrosis in mice
Mangiferin regulates the mRNA expression of proinflammatory cytokines, bile acid metabolism and pro-fibrotic related genes. Real time quantitative PCR were performed to detect the mRNA expression. (A) The mRNA expression levels of α-SMA, MMP2, TGF-β, COL1A1, COL3A1, PDGF and TIMP-2. (B) The mRNA expression levels of IL-1β, IL-6, MCP-1 and TNF-α. (C) The mRNA expression levels of ABCB4, ABCB11, SULT2A1, NTCP, SHP and CYP7A1. Date are presented as means ± S.E.M. (n = 8). #p < 0.05, ##p < 0.01 and ###p < 0.001, compared with control group. *p < 0.05, **p < 0.01 and ***p < 0.001, compared with CCl4 group. Ctrl, control group; CCl4, carbon tetrachloride treated group; L-MF, low dose of mangiferin (50 mg/kg); H-MF, high dose of mangiferin (100 mg/kg).
