Figure 3

ROC curves for the hypervariable region validated with a mock community microbial standard control. The cross-validation accuracy of the microbiota classifier is depicted by the ROC curve for the bacterial genera obtained: (A) AUC for V1–V2 = 0.736 (0.566–0.906); (B) AUC for V3–V4 = 0.474 (0.150–0.798); (C) AUC for V5–V7 = 0.462 (0.229–0.695); and (D) AUC for V7–V9 = 0.581 (0.297–0.865). As shown, a strong association existed between a specific microbiome genus composition and the V1–V2 hypervariable region. AUC area under the curve, ROC, receiver operating characteristic.