Figure 1 | Scientific Reports

Figure 1

From: Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula)

Figure 1

(a) Schematic illustration of the genomic organization of MHC class IIβ region using S. canicula reference genome sScyCan1.1 (BioProject PRJEB35945). Arrows indicate orientation of the MHC IIβ loci. SP, signal peptide; β1, peptide-binding domain; β2 immunoglobulin superfamily domain; CP, connecting piece; TM, transmembrane domain; CY, cytoplasmic tail. (b) Amino acid sequences of MHC IIβ exon 2 alleles (Scca-DBB). For readability purpose, only the most divergent alleles are shown. Shaded sites represented sites identified to evolve under positive selection according to the M8 model (CodeML). Amino acid residues expected to interact with antigen peptides are shown above the alignment (p) (Brown et al. 1993). For the purpose of comparison, the nurse shark (Ginglymostoma cirratum, AAF82682.1) and white shark (Carcharodon carcharias XP_041068366.1) sequences were added.

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