Figure 11

Increasing GPVI surface density increases dimerisation. (A) Simulation setups with various surface densities of GPVI: from left to right, top to bottom 50%, 100%, 150%, and 200% of σ0. (B) The plot shows that receptor dimerisation (as proportional to total GPVI, in %) increases with the GPVI surface density (as proportional to σ0 in %). Reference density σ0 was set as 533 molecules per μm2 (9600 receptors divided by platelet surface area ≈ 1.8 × 10–11 m2; spherical assumption).