Figure 3

Preferential localisation of single receptors in the confined domain. (A) Snapshots of 11 simulations of 47 receptors (red dots) moving on the simulated membrane with confined domain (yellow circle). Note the sub-micrometer size of the simulation box of 0.3 × 0.3 μm, and the initial random distribution of GPVI receptors. Simulations were run for ≥ 200,000 steps, with an average of the last 50,000 steps shown. The diffusivity ratio between outside and inside confined domains, Dout:Din, was changed from 1 (20) to 1024 (210). The snapshots shown are for Dout:Din = 1, 4, 16, 64, 256 and 1024. (B) Effect of an altered ratio Dout:Din on number of receptors inside the confined domain. Each simulation was repeated three times, means ± SD.