Figure 4 | Scientific Reports

Figure 4

From: An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts

Figure 4

Higher diffusivity ratio enhances receptor confinement and dimerisation. (A) Snapshots of simulation of receptors in monomeric (red) or dimeric (orange) forms in the presence of a confined domain (yellow circle). Initially, 47 monomeric receptors were randomly distributed without dimeric form. Simulations were run for ≥ 200,000 steps, with an average of the last 50,000 steps shown. The diffusivity ratio between outside and inside confined domains, Dout:Din, was varied from 1 (20) to 1024 (210). Snapshots are shown for Dout:Din = 1, 4, 16, 64, 256 and 1024. (B) Effect of altering the ratio of Dout:Din on the number of receptors in dimeric form. Simulations were repeated three times, means ± SD.

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