Table 4 Relationship of the regulatory polymorphisms with the overall survival (OS) of lung cancer patients, its subtypes, and TNM stages.

From: Identifying polymorphic cis-regulatory variants as risk markers for lung carcinogenesis and chemotherapy responses in tobacco smokers from eastern India

Regulatory polymorphisms

Genotypes

Dead

Alive

Median OS (Months)

Crude HR (95% CI)

Log-rank p-value*

Adjusted HR# (95% CI)

p-value*

[A] Overall Lung Cancer

 ALDH3B1-rs3764821A > G

AA

36

31

24

1 (Reference)

AG + GG

19

10

9

2.07 (1.13–3.79)

0.02*

2.12 (1.16–3.89)

0.015*

 RAD52-rs3748523C > G

CC

25

31

24

1 (Reference)

CG + GG

29

11

7

2.19 (1.25–3.87)

0.004**

2.32 (1.30–4.12)

0.004**

[B] Adenocarcinoma

 ALDH3B1-rs3764821A > G

AA

18

14

24

1 (Reference)

AG + GG

10

6

8.9

2.18 (0.93–5.15)

0.074

2.35 (0.99–5.59)

0.053

 RAD52-rs3748523C > G

CC

15

14

24

1 (Reference)

CG + GG

13

6

12

1.47 (0.67–3.21)

0.33

1.48 (0.68–3.22)

0.33

[C] Squamous Carcinoma

 ALDH3B1-rs3764821A > G

AA

16

16

24

1 (Reference)

AG + GG

4

3

8

1.33 (0.43–4.16)

0.6

1.25 (0.39–3.97)

0.71

 RAD52-rs3748523C > G

CC

6

14

24

1 (Reference)

CG + GG

14

2

6

5.25 (1.69–16.21)

0.001**

5.64 (1.76–18.1)

0.003**

[D] SCLC

 ALDH3B1-rs3764821A > G

AA

1

3

27

1 (Reference)

AG + GG

5

2

9

The sample size is insufficient

 RAD52-rs3748523C > G

CC

4

3

11

1 (Reference)

CG + GG

2

3

9

0.94 (0.15–5.66)

0.94

1.10 (0.17–7.17)

0.92

[E] Stage I + II (Early Stages)

 ALDH3B1-rs3764821A > G

AA

3

8

7

1 (Reference)

AG + GG

1

3

4.5

10.06 (1.04–96.66)

0.01*

2.78 (0.08–99,500,000)

0.14

 RAD52-rs3748523C > G

CC

2

8

12

1 (Reference)

CG + GG

4

1

6.5

5.73 (0.58–56.38)

0.09

219.87 (0.19–246,200)

0.83

[F] Stage III + IV (Late Stages)

 ALDH3B1-rs3764821A > G

AA

32

23

13

1 (Reference)

AG + GG

16

10

11

1.64 (0.84–3.18)

0.1

1.65 (0.84–3.85)

0.14

 RAD52-rs3748523C > G

CC

23

23

9

1 (Reference)

CG + GG

24

10

7

2.07 (1.13–3.79)

0.02*

2.32 (1.24–4.31)

0.008**

  1. p-value < 0.05*, 0.01**, 0.001***. Hazard ratios, 95% CI, and their corresponding p-values were calculated by Kaplan–Meier survival analysis after adjusting for remission and survival in months, and #adjusted hazard ratios, 95% CIs and their corresponding p-values were calculated by Cox regression models adjusted for age, sex, and pack-years of smoking.
  2. Significant values are in bold and italics.
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