Table 3 MR estimates from different methods of assessing the causal effect of VT on classical lipids.
From: A bidirectional Mendelian randomized study of classical blood lipids and venous thrombosis
Exposure-outcome | No. of SNP | IVW | Weighted median | Weighted mode | Simple mode | MR-Egger | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta (95%CI) | OR (95%CI) | P value | Cochran Q statistics (df) | Q-P value | Beta (95%CI) | P value | Beta (95%CI) | P value | Beta (95%CI) | P value | Beta (95%CI) | P value | Intercept (Se) | P value | Cochran Q statistics (df) | Q-P value | ||
DVT-LDL | 3 | 0.872 (− 1.631, 3.376) | 2.392 (0.195, 29.261) | 0.494 | 0.116 (2) | 0.943 | 0.859 (− 1.864, 3.582) | 0.536 | 0.833 (− 2.404, 4.072) | 0.663 | 0.741 (− 2.432, 3.915) | 0.692 | 2.854 (− 11.740, 17.449) | 0.766 | 0.023 | 0.831 | 0.043 (1) | 0.834 |
DVT-HDL | 3 | 0.183 (− 2.546, 2.913) | 1.201 (0.078,18.428) | 0.895 | 2.754 (2) | 0.252 | 0.585 (− 2.268, 3.440) | 0.687 | 1.117 (− 1.855, 4.090) | 0.538 | 0.407 (− 3.695, 4.510) | 0.863 | 10.277 (− 3.234, 23.789) | 0.376 | 0.021 | 0.377 | 0.545 (1) | 0.460 |
DVT-TG | 3 | 1.482 (− 0.759, 3.724) | 4.404 (0.467, 41.449) | 0.194 | 0.807 (2) | 0.667 | 1.645 (− 0.973, 4.264) | 0.218 | 1.766 (− 1.323, 4.856) | 0.379 | 1.913 (− 1.225, 5.052) | 0.354 | 6.872 (− 6.289, 20.035) | 0.492 | 0.021 | 0.564 | 0.143 (1) | 0.704 |
PE-LDL | 2 | 14.365 (− 28.58, 57.32) | 173 (3.83e−13, 7.83e + 24) | 0.512 | 40.648(1) | 1.82e−10 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
PE-HDL | 2 | − 3.516 (− 22.19, 15.16) | 0.0297 (2.29e−10,384) | 0.712 | 10.8 (1) | 0.001 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
PE-TG | 2 | 4.796 (− 0.656, 10.25) | 121.1 (0.518, 28,289) | 0.084 | 0.350 (1) | 0.554 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
