Figure 2
From: Renal toxicity and biokinetics models after repeated uranium instillation
Uranium tissue content of mice exposed to intranasal instillation. (a) Uranium retention in lungs, kidneys, gastrointestinal tract, and nasal compartments 1 h after the first instillation to uranium of 0.25 mg/kg. Each point represents an independent animal, and the square represents the SAAM II (Simulation, analysis, and modeling software for tracer and pharmacokinetic studies) biodosimetric model, n = 4. GIT gastro-intestinal tractus, NC nasal compartment. (b) Biodosimetric model of uranium content in the kidneys after repeated intranasal instillations (0.03–3 mg/kg/day) according to the quantity of uranium administered to mice. Each point represents an independent animal; n = 4–12 for each time and dose.
