Table 1 Body weight and weight gained or lost since day 1 of exposure to uranium.

From: Renal toxicity and biokinetics models after repeated uranium instillation

Dose (mg/kg/day)

Days post instillations

0

2

4

7

11

21

91

NE

Average weight (g)

24.4 ± 1.5

24.1 ± 1.8

24.2 ± 1.4

24.6 ± 1.5

24.3 ± 1.2

23.7 ± 2.2

29.8 ± 2.1

% Gain/lost since day 0

100

98.5 ± 3.5

99.1 ± 1.6

100.7 ± 2.6

98.3 ± 4.3

98.0 ± 3.8

120.5 ± 4.9

Number (n)

28

23

11

15

8

12

8

0.25

Average weight (g)

24.0 ± 1.2

23.6 ± 1.4

23.4 ± 1.1

23.9 ± 1.0

23.2 ± 1.1

24.6 ± 0.9

28.1 ± 1.8

% Gain/lost since day 0

100

98.1 ± 3.6

97.6 ± 1.9

98.4 ± 2.3

97.5 ± 2.3

97.8 ± 2.5

118.3 ± 6.6

Number (n)

28

24

11

15

8

12

8

1

Average weight (g)

24.2 ± 1.4

22.7 ± 1.4

22.9 ± 0.5

22.9 ± 0.8

23.0 ± 0.7

23.1 ± 1.1

ND

% Gain/lost since day 0

100

93.9 ± 2.7 ***

90.4 ± 2.4**

94.4 ± 3.9***

90.3 ± 2.2***

100.3 ± 4.2

 

Number (n)

20

16

4

8

4

4

 

3

Average weight (g)

24.3 ± 1.5

21.7 ± 1.6

20.2 ± 1.5

20.9 ± 2.3

21.1 ± 1.9

23.8 ± 1.7

27.9 ± 2.5

% Gain/lost since day 0

100

88.7 ± 3.5***

83.6 ± 2.4***

86.7 ± 3.6***

87.0 ± 4.6***

93.5 ± 1.2

115.0 ± 7.7

Number (n)

28

24

12

16

8

12

8

  1. The percentage of weight gain or loss is calculated for each animal and is related to its initial weight at D0. The number of animals decreases overall over time due to the successive animals’ euthanasia apart from the occasional absence of weighting due to technical constraints. NE non-exposed, uranium doses = 0.25, 1 or 3 mg/kg/day. Days = Time in days since the first day of exposure to uranium. *p < 0.05/**p < 0.01/***p < 0.001, comparison with non-exposed animals, Two-way ANOVA.
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