Table 2 Measurement of urine volumes, feces and glomerular filtration rate after uranium exposure.

From: Renal toxicity and biokinetics models after repeated uranium instillation

Dose (mg/kg/day)

Days post instillations

2

4

7

11

21

91

NE

Diuresis (mL)

0.83 ± 0.36

0.84 ± 0.29

0.83 ± 0.22

0.62 ± 0.35

0.68 ± 0.44

0.99 ± 0.55

GFR (mL/min/kg)

2.9E−6 ± 1.4E−6

2.9E−6 ± 1.0E−6

2.8E−6 ± 0.2E−6

2.6E−6 ± 1.5E−6

1.7E−6 ± 1.1E−6

2.1E−6 ± 0.7E−6

Feces (g)

1.07 ± 0.27

1.15 ± 0.33

1.29 ± 0.15

0.94 ± 0.23

0.90 ± 0.38

0.75 ± 0.36

Number (n)

4

4

4

3

4

8

0.25

Diuresis (mL)

0.59 ± 0.36

0.87 ± 0.17

0.98 ± 0.16

0.74 ± 0.30

0.58 ± 0.26

0.83 ± 0.28

GFR (mL/min/kg)

2.4E−6 ± 0.8E−6

3.9E−6 ± 1.4E−6

2.9E−6 ± 0.7E−6

3.7E−6 ± 2.1E−6

2.4E−6 ± 0.9E−6

2.8E−6 ± 0.7E−6

Feces (g)

1.13 ± 0.28

1.23 ± 0.26

1.29 ± 0.05

1.15 ± 0.18

1.23 ± 0.16

0.49 ± 0.18

Number (n)

4

4

4

3

4

8

1

Diuresis (mL)

0.63 ± 0.25

0.76 ± 0.27

1.11 ± 0.49

0.51 ± 0.38

0.65 ± 0.23

ND

GFR (mL/min/kg)

2.4E−6 ± 0.4E−6

2.9E−6 ± 1.7E−6

2.0E−6 ± 1.4E−6

1.2E−6 ± 0.4E−6

2.6E−6 ± 0.6E−6

 

Feces (g)

1.09 ± 0.22

0.73 ± 0.54

1.14 ± 0.26

0.87 ± 0.19

1.22 ± 0.35

ND

Number (n)

4

4

4

4

4

 

3

Diuresis (mL)

0.53 ± 0.50

0.96 ± 0.70

1.95 ± 0.57 **

1.88 ± 1.41

1.03 ± 0.49

1.39 ± 0.81

GFR (mL/min/kg)

0.9E−6 ± 0.8E−6

0.8E−6 ± 0.4E−6

2.6E−6 ± 2.0E−6

1.1E−6 ± 0.3E−6

2.4E−6 ± 0.7E−6

3.7E−6 ± 2.3E−6

Feces (g)

0.36 ± 0.42 *

0.17 ± 0.05 *

0.61 ± 0.33 **

0.26 ± 0.18 **

1.17 ± 0.21

0.74 ± 0.29

Number (n)

4

4

4

4

4

8

  1. NE non-exposed, GFR glomerular filtration rate
  2. *P < 0.05/**P < 0.01/***P < 0.001, comparison with unexposed animals, Two-way ANOVA.
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