Figure 1 | Scientific Reports

Figure 1

From: Inhibition of NHE1 transport activity and gene transcription in DRG neurons in oxaliplatin-induced painful peripheral neurotoxicity

Figure 1

Intrinsic buffering power in DRG neurons. (a) Intrinsic buffering power (βi) as a function of pHi. βi values were estimated, in single untreated DRG neurons or treated with OHP and AMI, from Δ pHi measured upon removal of NH4Cl (mM) pulses in Na+-free solution. Data were collected from 3 to 6 different cultures for each condition. (b) Mean (square), median (line across the box), interquartile range (box), maximum and minimum (Hyphens over and under the box) of βi values from (a) at five ranges of pHi for untreated (CTRL), AMI- and OHP-treated neurons. (c) Mean and SEM of pooled βi values from the different experimental conditions at the five ranges of pHi. Solid red line represents a single exponential decay fitting curve, namely: βi = 0.006 + 0.051*exp( − (pHi − 6.28)/0.185).

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