Figure 4 | Scientific Reports

Figure 4

From: Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure

Figure 4

(a) MicroCT analysis of different structural variables. Tibial length, BV (bone volume), B.Pm (bone perimeter), CsTh (cross-sectional thickness), Mineral Density (MD), BV/TV (bone volume/tissue volume), Tb.N (trabecular number), Tb.Th (trabecular thickness), Tb.Sp (trabecular space). (b) 3D reconstruction of the analyzed ROI. First and third columns corresponding to cortical bone and second and fourth to trabecular bone. Scale bar = 0.2 mm. (c) Results of three-point bending test. Data represented as maximum load resisted by the bones, force at fracture, stiffness, and total energy absorbed by the bones during the experiment. Data are presented as fold change expression versus Null treated animals. Mean ± Standard error of the mean (SEM), n = 4–6; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.001 for differences between the treatment groups.

Back to article page