Figure 6 | Scientific Reports

Figure 6

From: CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death

Figure 6

L-Moses attenuates Tun-mediated transcriptional changes on dopaminergic neurons. (A) Co-treatment with L-Moses rescues Tun-mediated cell death in a dose dependent manner, as shown by MTS assay. (B) L-Moses reduces Tun response (Tun-treated minus Unt MFI) in a dose dependent manner. (C) Circos plot showing the overlap (purple lines) between genes upregulated by Tun and downregulated by Tun + L-Moses and vice versa. (D) Hierarchical clustering of GO Biological Processes terms upregulated or downregulated in Tun versus Tun + L-Moses. (E) GO Biological Processes terms enriched in the genes that overlap between the ones upregulated by 100 nM Tun and downregulated by Tun + L-Moses.

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