Table 2 Receiver operating characteristics (ROC) and area under the curves (AUC) for different cell cycle points.

From: Embryo morphokinetics derived from fresh and vitrified bovine oocytes predict blastocyst development and nuclear abnormalities

Division (no. blastomeres)

n

AUC (95% CI)

Cut-off

Se

Sp

First division (1–2 cells)

313

0.72 (0.65–0.78)

32 h 22 min

0.70

0.66

Second division (3–4 cells)

272

0.57 (0.50–0.64)

42 h 42 min

0.81

0.42

Third division (5–8 cells)

238

0.51 (0.44–0.59)

53 h 18 min

0.89

0.29

Fourth division (9–16 cells)

163

0.50 (0.40–0.61)

69 h 49 min

0.87

0.33

  1. n = number of zygotes/embryos analyzed. Se: sensitivity, proportion of zygotes predicted with positive outcome that will be blastocyst. Sp: specificity, proportion of zygotes predicted with negative outcome that will be arrested embryos.
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