Figure 5
From: The impact of pericytes on the stability of microvascular networks in response to nanoparticles
The impact of pericytes on network stability in response to starvation. (A) 72 h nutrient starvation resulted in the entire collapse of HUVEC networks in monocultures. In contrast, HUVEC/ pericyte networks persisted, although they apparently regressed compared with untreated conditions (mean ± SEM total tube length, 10.7 ± 0.7 vs 13.5 ± 0.6 mm/field of view, respectively). (B) Impact of starvation on tube diameter in co-cultures, showing no significant difference after starvation. (C) Representative images, z-projection images were generated using confocal images. Red, CD31. Scale bar: 300 µm. N = 3; n.s., non significant; *, p < 0.05; ***, p < 0.001.
