Figure 2 | Scientific Reports

Figure 2

From: Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition

Figure 2

The cell cycles arrest induction by melatonin treatment. The effect of melatonin doses (1 mM, and 2.5 mM) for 24 h on HepG2 cell cycle distribution using flowcytometry is shown in representative charts (a) Cell cycle distribution in control vehicle untreated HepG2 cells, (b) cell cycle distribution in 1 mM melatonin treated HepG2 cells, (c) cell cycle distribution in 2.5 mM melatonin treated HepG2 cells, (d) the cell cycle distribution column chart of 1 mM melatonin-treated HepG2 cells, and (e) the cell cycle distribution column chart of 2.5 mM melatonin-treated HepG2 cells. Melatonin was detected to increase the accumulation of HepG2 cells in the G0/G1 phase of the cell cycle in percentages of 70.20% and 75.70% at melatonin concentrations of 1 mM and 2.5 mM, respectively. The experiment was repeated in triplicate. ***P < 0.001, **P < 0.01, and *P < 0.05 as compared to control.

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