Figure 3 | Scientific Reports

Figure 3

From: Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model

Figure 3

Functional analysis of human dystrophin derived from human artificial chromosome in skeletal muscles. (A) H&E staining of skeletal muscles of WT, DMD-null, and DYS-HAC1; DMD-null mice at more than 8 weeks of age. Scale bar is 50 μm. (B) CK activity in WT (n = 19), DMD-null (n = 14), and DYS-HAC1; DMD-null mice (n = 9) at more than 8 weeks of age. (C) Voluntary wheel running in WT (n = 13), DMD-null (n = 8), and DYS-HAC1; DMD-null mice (n = 9) at more than 8 weeks of age. Tukey’s multiple comparisons test was performed. ***P < 0.001. NS nonsignificant.

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