Table 3 Results of Logistic regression models of the effect of PGS cut-offs on risk of prevalent and incident diabetes.

From: A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study

 

Outcome: Prevalent T2D

Outcome: Incident T2D

OR*

CI (95%)

p-value

OR*

CI (95%)

p-value

Upper 20% of PGS

19.16

[13.65–27.27]

 < 2 × 10–16

2.16

[1.45–3.18]

1.21 × 10–4

Upper 10% of PGS

32.09

[22.21–47.05]

 < 2 × 10–16

2.95

[1.68–4.99]

9.35 × 10–5

Upper 5% of PGS

47.03

[29.69–76.26]

 < 2 × 10–16

4.94

[2.00–11.35]

2.67 × 10–4

  1. All models were adjusted for age, sex, BMI, physical activity and FamRS.
  2. *OR is given for those above this cut-off with the remainder of the population as the reference.
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