Table 4 Results of Logistic regression models of the effect of FamRS on risk of prevalent and incident diabetes

From: A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study

 

FamRS categories

Outcome: Prevalent T2D

Outcome: Incident T2D

OR*

CI (95%)

p-value

OR*

CI (95%)

p-value

Unadjusted

FamRS 2

2.08

[1.45–2.92]

4.05 × 10–5

1.40

[0.85–2.19]

0.165

FamRS 3

4.73

[3.04–7.20]

1.77 × 10–14

3.46

[1.85–6.09]

5.89 × 10–5

Adjusted for Age + Sex + BMI + Physical activity

FamRS 2

2.47

[1.67–3.61]

4.30 × 10–6

1.60

[0.95–2.58]

0.062

FamRS 3

4.33

[2.65–6.95]

2.17 × 10–9

3.74

[1.94–6.82]

3.49 × 10–5

Adjusted for Age + Sex + BMI + Physical activity + PGS

FamRS 2

1.67

[1.01–2.71]

0.041

1.45

[0.86–2.35]

0.149

FamRS 3

2.78

[1.49–5.09]

0.001

3.47

[1.79–6.35]

1.07 × 10–4

  1. *ORs are given for FamRS categories “positive and strong positive family risk” (FamRS 2) and “very strong positive family risk” (FamRS 3) compared to average family risk.
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