Figure 4

Pre-surgical total cholesterol values inversely correlate with the tumor diameter in dependence of the grading/the TNM classification. (a) Total cholesterol values before surgery in dependence of the grading (Mean: G1: 198.8; G2: 164.4; G3: 182.7; control group: 186.4). (b) Direct correlation between the total cholesterol values before surgery and the tumor diameter of all LUAD patients (G1 + G2 + G3) in dependence of the grading (n = 65, p = 0.0391, R² = 0.06584). (c) Direct correlation between the total cholesterol values before surgery and the tumor diameter of all LUAD patients with G3 in dependence of the grading (n = 30, p = 0.0232, R² = 0.1709). (d) Total cholesterol values before surgery in dependence of the TNM classification (Mean: Stage I: 183.2; Stage II: 173.6; Stage III: 165.9; Stage IV: 160.3; Control group: 186.4). (e) Direct correlation between the total cholesterol values before surgery and the tumor diameter of all LUAD patients (Stage I + II + III + IV) in dependence of the TNM classification (n = 67, p = 0.0360, R² = 0.06591). (f) Direct correlation between the total cholesterol values before surgery and the tumor diameter of all LUAD patients with Stage II in dependence of the TNM classification (n = 12, p = 0.0203, R² = 0.4315). (g) Direct correlation between the total cholesterol values before surgery and the CRP values before surgery of all LUAD patients with G2 in dependence of the grading (n = 26, p = 0.0207, R² = 0.2037). (h) Kaplan–Meier curve depending on total cholesterol level in the serum before surgery (blue line: total cholesterol ≤ 200 mg/dl: n = 45; red line: total cholesterol > 200 mg/dl: n = 22). Correlations are shown by using simple linear regression. Data are shown as mean values ± s.e.m.