Figure 1
From: Characterization of pancreatic cancer with ultra-low tumor mutational burden
(a) Flow diagram of patient enrollment and sample collection. From January 2014 to March 2019, a total of 103 cases of PC were analyzed in Project HOPE. Tumor tissue samples were collected from resected specimens by pathologists, and all tumor tissues were pathologically diagnosed as PC. Ninety-three resected PC cases with available data for WES, CCP, and GEP were enrolled in this study. (b) Distribution of the TMB and its classification. The median TMB was 0.238, with an interquartile range of 0.15–0.64. No samples (0.0%) had a TMB ≥ 5.00 mutations/Mb (TMB-high). Nineteen samples (20%) had 1 to < 5 mutations/Mb, defined as TMB-low, and 74 tumors had < 1.0 mutation/Mb, defined as TMB ultra-low (80%).
