Figure 1 | Scientific Reports

Figure 1

From: Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons

Figure 1

Prostaglandins biosynthesis pathway. Cyclooxygenases (COX) metabolize arachidonic acid first to prostaglandin G2 (PGG2) and then to prostaglandin H2 (PGH2). COX1 and 2 are targeted by non-steroidal anti-inflammatory drugs (NSAIDs), which block the synthesis of prostaglandins. PGH2 is converted to prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), prostaglandin I2 (PGI2), prostaglandin F2α (PGF2α) and thromboxane A2 (TXA2) by respective synthases. Each prostaglandin binds to specific receptors, which are members of the G protein-coupled receptor (GCPR) superfamily of seven transmembrane proteins, activating different downstream signaling pathways. cAMP cyclic adenosine monophosphate, IP3 inositol triphosphate.

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