Figure 2 | Scientific Reports

Figure 2

From: Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons

Figure 2

Most prostaglandin studies have not been analyzed with sex as a biological variable. (A) Line plot showing the inclusion of male, female or both sexes in pre-clinical studies from 1973 to 2020 and the number of studies that have been analyzed separated by sex (red line). (B) Pie charts showing the overall percentage of pre-clinical studies that include male, female or both sexes from 1973 to 2020. (C) Line plot showing the inclusion of male, female or both sexes in clinical studies from 1969 to 2020, including the studies that have analyzed the data separated by sex (red line). (D) Pie charts showing the overall percentage of clinical studies that include male, female or both sexes from 1969 to 2020. Note: studies where the sex of animals/subjects is not clear or specified are not shown in the line plots, please refer to supplementary files 1–4.

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